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In recent years, it has also become apparent that contaminated (i.e., the presence of a pathogen from outside the blood stream) blood cultures are common, leading to falsely positive test results.( 1,2) Contaminated blood cultures constitute as many as half or more of all positive blood cultures in some centers, are very costly to patients and the health care system,( 3) and are confusing for clinicians.( 4,5) Physicians and clinical microbiologists have long appreciated that blood cultures are perhaps the most important laboratory tests to diagnose serious infections.
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